Traumatic Brain Injury

What is happening in a traumatic brain injury or concussion? The brain has about 10 billion capillaries in a highly specialized endothelial lining flush with tight junctions, basement membranes, pericytes & astrocyte projections. This blood-brain barrier (BBB) admits molecules sized at 400 daltons and less (as a comparison, alcohol is 200 daltons per molecule which […]

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The Brain-Vagus-Gut Connection

The connection between our guts and our brains cannot be denied. While the relationship between the gut and the brain has been known since the 19th century in terms of control of peristalsis, or motility, we have developed a greater understanding of just how important the crosstalk is between the two organs. The burgeoning field […]

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MAST CELLS AND AUTONOMIC DYSFUNCTION

Mast cells are implicated in a wide array of disorders. At one extreme is mastocytosis with a true proliferation of mast cells. At the other end, and often all in between, are the mast cell activation disorders where there is episodic activation and degranulation of mast cells and release of their contents, mainly histamine, causing […]

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